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Recent Research
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![mRNA-PD1 cancer vaccine trial control arm may have underperformed](https://static.wixstatic.com/media/f1a3c6_7f4b4095586a4793bda38d9a23959441.jpg/v1/fill/w_319,h_180,fp_0.50_0.50,q_90,enc_auto/f1a3c6_7f4b4095586a4793bda38d9a23959441.webp)
Apr 18, 2023
mRNA-PD1 cancer vaccine trial control arm may have underperformed
In newly published data from Merck /Moderna’s PD1 + mRNA cancer vaccine trial, efficacy may be flattered by Keytruda alone control arm under
![](https://static.wixstatic.com/media/f1a3c6_7f4b4095586a4793bda38d9a23959441.jpg/v1/fill/w_250,h_250,fp_0.50_0.50,q_30,blur_30,enc_auto/f1a3c6_7f4b4095586a4793bda38d9a23959441.webp)
![Little hope in TIGIT trials to date](https://static.wixstatic.com/media/f1a3c6_7f4b4095586a4793bda38d9a23959441.jpg/v1/fill/w_319,h_180,fp_0.50_0.50,q_90,enc_auto/f1a3c6_7f4b4095586a4793bda38d9a23959441.webp)
Mar 20, 2023
Little hope in TIGIT trials to date
As expected, TIGIT addition to PD1 failed to beat chemo in second-line patients.
The failure of Merck’s TIGIT+PD1 combo to beat second line
![](https://static.wixstatic.com/media/f1a3c6_d018a78cb2bf4ace86a6e07570660a81~mv2.jpg/v1/fill/w_250,h_250,fp_0.50_0.50,q_30,blur_30,enc_auto/f1a3c6_d018a78cb2bf4ace86a6e07570660a81~mv2.webp)
![PFE pipeline Swim in a big pond if you're 2nd to jump in](https://static.wixstatic.com/media/f1a3c6_d018a78cb2bf4ace86a6e07570660a81~mv2.jpg/v1/fill/w_319,h_319,fp_0.50_0.50,q_90,enc_auto/f1a3c6_d018a78cb2bf4ace86a6e07570660a81~mv2.webp)
Dec 21, 2022
PFE pipeline Swim in a big pond if you're 2nd to jump in
We examine in detail, the prospects of five near term Pfizer pipeline assets, slated for the FDA over the next 3 years and find that there a
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![ROG: No rays of hope for TIGIT at ASCO2022](https://static.wixstatic.com/media/f1a3c6_7f4b4095586a4793bda38d9a23959441.jpg/v1/fill/w_319,h_180,fp_0.50_0.50,q_90,enc_auto/f1a3c6_7f4b4095586a4793bda38d9a23959441.webp)
Jun 22, 2022
ROG: No rays of hope for TIGIT at ASCO2022
Roche recently announced the failure of co-primary progression free survival endpoints in both of its 1st line TIGIT trials in non-small (SK
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![PD1 Combos at ESMO good for AZN and BMY not for MRK and ROG](https://static.wixstatic.com/media/f1a3c6_093d4b33e37a4c588937e60c8107329b~mv2_d_1800_1800_s_2.jpg/v1/fill/w_319,h_319,fp_0.50_0.50,q_90,enc_auto/f1a3c6_093d4b33e37a4c588937e60c8107329b~mv2_d_1800_1800_s_2.webp)
Oct 17, 2016
PD1 Combos at ESMO good for AZN and BMY not for MRK and ROG
Chemo combos continue to look equivocal, while IO combos remain durable as MYSTIC’s shadow clears New ESMO lung cancer data bodes well...
![Unravelling the MYSTICal](https://static.wixstatic.com/media/f1a3c6_33c2d240ed884e45921e99b81fc1176c~mv2_d_1800_1800_s_2.png/v1/fill/w_319,h_319,fp_0.50_0.50,q_95,enc_auto/f1a3c6_33c2d240ed884e45921e99b81fc1176c~mv2_d_1800_1800_s_2.webp)
Oct 13, 2016
Unravelling the MYSTICal
Astra's underappreciated oncology pipeline stalking the market We initiate on AstraZeneca with an overweight rating and a Target Price of...
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![ESMO 2016: all anti PD1/PDL1 checkpoint inhibitors are not the same](https://static.wixstatic.com/media/f1a3c6_7f4b4095586a4793bda38d9a23959441.jpg/v1/fill/w_319,h_180,fp_0.50_0.50,q_90,enc_auto/f1a3c6_7f4b4095586a4793bda38d9a23959441.webp)
Sep 30, 2016
ESMO 2016: all anti PD1/PDL1 checkpoint inhibitors are not the same
Pressure on anti PD-L1s: ESMO 2016 increases the body of evidence that anti PD-L1s from Roche, Astra and PFE/MRCG may fall short of PD-1s...
![](https://static.wixstatic.com/media/f1a3c6_86c4ed85395a4d138206dc5bc8e66071~mv2_d_1800_1800_s_2.jpg/v1/fill/w_250,h_250,fp_0.50_0.50,q_30,blur_30,enc_auto/f1a3c6_86c4ed85395a4d138206dc5bc8e66071~mv2_d_1800_1800_s_2.webp)
![Consensus PD1 hopes under threat](https://static.wixstatic.com/media/f1a3c6_86c4ed85395a4d138206dc5bc8e66071~mv2_d_1800_1800_s_2.jpg/v1/fill/w_319,h_319,fp_0.50_0.50,q_90,enc_auto/f1a3c6_86c4ed85395a4d138206dc5bc8e66071~mv2_d_1800_1800_s_2.webp)
Aug 8, 2016
Consensus PD1 hopes under threat
PD1 market continues to shrink, but Bristol’s failure not good news for rivals BMY announced Friday that its pivotal phase III study of...
![](https://static.wixstatic.com/media/f1a3c6_7f4b4095586a4793bda38d9a23959441.jpg/v1/fill/w_250,h_250,fp_0.50_0.50,q_30,blur_30,enc_auto/f1a3c6_7f4b4095586a4793bda38d9a23959441.webp)
![ASCO Steep climb for Bristol competitors in 1st and 2nd line lung cancer](https://static.wixstatic.com/media/f1a3c6_7f4b4095586a4793bda38d9a23959441.jpg/v1/fill/w_319,h_180,fp_0.50_0.50,q_90,enc_auto/f1a3c6_7f4b4095586a4793bda38d9a23959441.webp)
Jun 8, 2016
ASCO Steep climb for Bristol competitors in 1st and 2nd line lung cancer
Pressure on consensus: We have long argued all IO competitors will have to better Bristol’s Opdivo + Yervoy combination in the biggest...
![](https://static.wixstatic.com/media/f1a3c6_b3ad114a39954132aeab3ebe840956ca~mv2_d_4680_4680_s_4_2.jpg/v1/fill/w_250,h_250,fp_0.50_0.50,q_30,blur_30,enc_auto/f1a3c6_b3ad114a39954132aeab3ebe840956ca~mv2_d_4680_4680_s_4_2.webp)
![ASCO data closing in on PD1 market](https://static.wixstatic.com/media/f1a3c6_b3ad114a39954132aeab3ebe840956ca~mv2_d_4680_4680_s_4_2.jpg/v1/fill/w_319,h_319,fp_0.50_0.50,q_90,enc_auto/f1a3c6_b3ad114a39954132aeab3ebe840956ca~mv2_d_4680_4680_s_4_2.webp)
May 26, 2016
ASCO data closing in on PD1 market
New ASCO 2016 data continues to support lower than consensus potential revenues, modest anti PD-L1 efficacy and more doubts over chemo...
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